Intact Mass
We can help you determine the whole intact mass of your recombinant protein or biologic sample. Intact Mass offers a “bird’s eye view” direct observation of mixtures of intact protein isoforms to monitor isoform heterogeneity and polydispersity. Observed isoform masses can be accurately matched to calculated masses of possible or expected isoforms to quickly verify recombinant protein expression or monitor sample micro-heterogeneity. Innomics scientists at the San Jose Mass Spec Center have developed cutting edge Intact Mass services including Native MS utilizing multiple HPLC separation strategies combined with high resolution Orbitrap mass spectrometry.
Features and Advantages
Analytical services and downstream support for biopharmaceutical and biotechnology clients
Innovative analysis: Detailed knowledge about the molecular composition of biologics samples for dynamic range and sensitivity analyses
Cutting-edge LC-MS platform: Supports diverse biologics characterization projects, including highly complex samples such as bi-/multi-specific antibodies, ADCs, and Fc-fusion protein drugs
Pioneered native LC-MS technology: Preserves non-covalent binding and is compatible with medium-to-high-throughput sample analysis
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